circRNA basic information
circBase ID: -
Name: -
Synonym: CircRNA_002178
Host Gene: hsa-miR-542-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CREB1
Associated microRNA: hsa-miR-542-3p
Biological function: The circ_002178 knockdown inhibited the proliferation, invasion, colony formation, and glycolysis of the CRC cells in vitro, but the overexpression of circ_002178 induced the opposite result (both P<0.05)
Molecular mechanism: circ_002178, as the molecular sponge of hsa-miR-542-3p, promotes CREB1 expression
Survival: -
Supported No.:
 1
Description:

circ_002178 promotes the invasion, proliferation, colony formation, and glycolysis of CRC cells by regulating the miR-542-3p/CREB1 axis, thus driving the development of CRC.
Other information
Title:

CircRNA_002178 as a ceRNA promotes the development of colorectal cancer by regulating miR-542-3p/CREB1.

Journal: Am J Transl Res
Published: 2021/10/16
PubMed ID: 34650680