circRNA basic information
circBase ID: -
Name: hsa_circ_IPO11
Synonym: circIPO11
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3571
DO name: liver cancer
Disease details: liver cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cell lines (Huh7, PLC/PRF/5)
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: CircIPO11 is required for the self-renewal maintenance of liver CSCs to initiate HCC development.
Molecular mechanism: circIPO11 recruits TOP1 to GLI1 promoter to trigger its transcription, leading to the activation of Hedgehog signaling.
Survival: -
Supported No.:
 2
Description:

circIPO11 drives the self-renewal of liver CSCs and promotes the propagation of HCC via activating Hedgehog signaling pathway. Antisense oligonucleotides (ASOs) against circIPO11 combined with TOP1 inhibitor camptothecin (CPT) exert synergistic antitumor effect.

Other information
Title:

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Journal: Mol Cancer
Published: 2021/10/16
PubMed ID: 34649567