circRNA basic information
circBase ID: hsa_circ_0045714
Name: -
Synonym: Circ_0045714
Host Gene: hsa-miR-331-3p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: immortalized HAC cell line (CHON-001; CRL-2846; ATCC, Manassas, VA, USA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PIK3R3
Associated microRNA: hsa-miR-331-3p
Biological function: -
Molecular mechanism: circ_0045714 functioned as competing endogenous RNA (ceRNA) for hsa-miR-331-3p and further regulated expression of the downstream target gene PIK3R3
Survival: -
Supported No.:
 4
Description:

Expression of circ_0045714 and phosphoinositide-3-kinase (PI3K) regulatory subunit 3 (PIK3R3) was declined, and microRNA (miR)-331-3p was promoted in knee articular cartilages and cells from OA patients, as well as interleukin (IL)-1beta-challenged human articular chondrocytes (HAC) cell line.
Other information
Title:

Circ_0045714/miR-331-3p interaction affects IL-1beta-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade.

Journal: J Orthop Surg Res
Published: 2021/10/16
PubMed ID: 34649564