circRNA basic information
circBase ID: -
Name: hsa_circ_HN1
Synonym: -
Host Gene: hsa-miR-628-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NT5E
Associated microRNA: hsa-miR-628-5p
Biological function: Depletion of circ_HN1 impeded cell proliferation, spheroid formation, invasion, and migration and promoted apoptosis in vitro
Molecular mechanism: circ_HN1/hsa-miR-628-5p/NT5E axis
Survival: -
Supported No.:
 4
Description:

circ_HN1 expression was enhanced in human gastric cancer. Depletion of circ_HN1 impeded cell proliferation, spheroid formation, invasion, and migration and promoted apoptosis in vitro, as well as diminished tumor growth in vivo. NT5E was a downstream effector of circ_HN1 function.
Other information
Title:

A novel circular RNA circ_HN1/miR-628-5p/Ecto-5-nucleotidase competing endogenous RNA network regulates gastric cancer development.

Journal: Bioengineered
Published: 2021/10/13
PubMed ID: 34637682