circRNA basic information
circBase ID: -
Name: hsa_circ_COG2
Synonym: circCOG2
Host Gene: hsa-miR-1305
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGF-beta2/SMAD3
Associated microRNA: hsa-miR-1305
Biological function: Upregulated circCOG2 promoted CRC proliferation, migration, and invasion
Molecular mechanism: through the hsa-miR-1305/TGF-beta2/SMAD3 pathway
Survival: poor
Supported No.:
 1
Description:

Upregulated circCOG2 promoted CRC proliferation, migration, and invasion through the miR-1305/TGF-beta2/SMAD3 pathway, and this effect could be transmitted from CRC cells with the high metastatic potential to CRC cells with low metastatic potential by exosomes.
Other information
Title:

Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-beta2/SMAD3 pathway.

Journal: Cell Death Discov
Published: 2021/10/13
PubMed ID: 34635639