circRNA basic information
circBase ID: -
Name: hsa_circ_ATAD1
Synonym: circ-ATAD1
Host Gene: hsa-miR-34b
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34b
Biological function: AML cell proliferation was increased by circ-ATAD1 overexpression
Molecular mechanism: circ-ATAD1 overexpression in AML cells decreased hsa-miR-34b expression and increased hsa-miR-34b gene methylation
Survival: -
Supported No.:
 1
Description:

circ-ATAD1 as a nucleus-specific circRNA in AML, which promotes AML cell proliferation by downregulating miR-34b via methylation.
Other information
Title:

Circular RNA ATAD1 is upregulated in acute myeloid leukemia and promotes cancer cell proliferation by downregulating miR-34b via promoter methylation.

Journal: Oncol Lett
Published: 2021/10/12
PubMed ID: 34630706