circRNA basic information
circBase ID: -
Name: hsa_circ_CDC45
Synonym: CircCDC45
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CSF-1
Associated microRNA: hsa-miR-485-5p
Biological function: Downregulation of circCDC45 or CSF-1 blocked GBM cell proliferation, invasion and migration as well as tumor growth in vivo
Molecular mechanism: circCDC45 positively regulated the expression of CSF-1 by targeting hsa-miR-485-5p
Survival: -
Supported No.:
 1
Description:

CircCDC45 promoted the progression of GBM by mediating the miR-485-5p/CSF-1 axis, and circCDC45 might be a promising plasmatic biomarker for GBM diagnosis and treatment.
Other information
Title:

CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis.

Journal: BMC Cancer
Published: 2021/10/11
PubMed ID: 34627193