circRNA basic information
circBase ID: -
Name: hsa_circ_CRKL
Synonym: circCRKL
Host Gene: hsa-miR-196a-5p, hsa-miR-196b-5p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: p27
Associated microRNA: hsa-miR-196a-5p, hsa-miR-196b-5p
Biological function: inhibited the proliferation and colony-forming ability
Molecular mechanism: circCRKL could sponge hsa-miR-196a-5p and hsa-miR-196b-5p to promote the expression of p27
Survival: -
Supported No.:
 1
Description:

circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy.
Other information
Title:

Circular RNA circCRKL inhibits the proliferation of acute myeloid leukemia cells via the miR-196a-5p/miR-196b-5p/p27 axis.

Journal: Bioengineered
Published: 2021/10/8
PubMed ID: 34617876