circRNA basic information
circBase ID: hsa_circ_0006349
Name: -
Synonym: Circ_0006349
Host Gene: hsa-miR-98
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Calu-3, H1299 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MKP1
Associated microRNA: hsa-miR-98
Biological function: Silencing of circ_0006349 suppressed proliferation and increased apoptosis of Calu-3 and H1299 cells, and it reduced glycolysis, glucose uptake, and the production of lactate in cells
Molecular mechanism: Circ_0006349 was identified as a sponge for hsa-miR-98 to elevate MKP1 expression.
Survival: -
Supported No.:
 1
Description:

This research demonstrated that circ_0006349 derepressed MKP1 expression by absorbing miR-98, which augmented the proliferation and glycolysis of NSCLC cells and promoted cancer development.
Other information
Title:

Circular RNA 0006349 Augments Glycolysis and Malignance of Non-small Cell Lung Cancer Cells Through the microRNA-98/MKP1 Axis.

Journal: Front Cell Dev Biol
Published: 2021/10/5
PubMed ID: 34604211