circRNA basic information
circBase ID: -
Name: hsa_circ_IMMP2L
Synonym: CircIMMP2L
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CtBP1 and HDAC1
Associated microRNA: -
Biological function: CircIMMP2L depletion suppressed the malignant progression of ESCC both in vitro and in vivo
Molecular mechanism: cytoplasmic circIMMP2L interacted with CtBP1 and facilitated the nuclear retention of CtBP1 in a CtBP2-independent manner
Survival: poor
Supported No.:
 1
Description:

circIMMP2L promotes the malignant progression of ESCC mediated by CtBP1 nuclear retention and is a robust biomarker for the diagnosis, prognosis, and LNM in ESCC.
Other information
Title:

CircIMMP2L promotes esophageal squamous cell carcinoma malignant progression via CtBP1 nuclear retention dependent epigenetic modification.

Journal: Clin Transl Med
Published: 2021/9/30
PubMed ID: 34586741