circRNA basic information
circBase ID: hsa_circ_0000073
Name: hsa_circ_OMA1
Synonym: -
Host Gene: hsa-miR-1252-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCNE2 and MDM2
Associated microRNA: hsa-miR-1252-5p
Biological function: hsa_circ_0000073 was highly expressed in OS cell lines and could promote OS progression, including proliferation, migration, invasion, and cell cycle in vitro as well as tumorigenesis in vivo.
Molecular mechanism: hsa_circ_0000073 could readily downregulate the expression of CCNE2 and MDM2 through hsa-miR-1252-5p
Survival: -
Supported No.:
 4
Description:

hsa_circ_0000073 functions as a tumor promoter in OS to increase malignant tumor behavior through sponging miR-1252-5p and regulating CCNE2 and MDM2 expression, which could be a novel target for OS therapy.
Other information
Title:

Circular RNA hsa_circ_0000073 Enhances Osteosarcoma Cells Malignant Behavior by Sponging miR-1252-5p and Modulating CCNE2 and MDM2.

Journal: Front Cell Dev Biol
Published: 2021/9/28
PubMed ID: 34568326