circRNA basic information
circBase ID: hsa_circ_0006948
Name: -
Synonym: Circ_0006948
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (EJ, T24, 253j, J82, 5637), urothelial cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EMT signaling
Associated microRNA: -
Biological function: Knockdown of circ_0006948 reduced proliferative and metastatic abilities in BC cells
Molecular mechanism: The key protein in the EMT signaling E-cadherin was upregulated by knockdown of circ_0006948 in BC cells, while N-cadherin, Vimentin, beta-catenin and MMP-9 were downregulated
Survival: poor
Supported No.:
 1
Description:

Circ_0006948 is upregulated in BC samples, and it is closely linked to tumor stage, metastasis and prognosis in BC patients. It drives proliferative and metastatic abilities in BC cells by activating EMT.
Other information
Title:

Circ_0006948 drives the malignant development of bladder cancer via activating the epithelial-mesenchymal transition.

Journal: J BUON
Published: 2021/9/27
PubMed ID: 34565009