circRNA basic information
circBase ID: -
Name: hsa_circ_CCND1
Synonym: circ-CCND1
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-497-5p
Biological function: knockdown of circ-CCND1 remarkably suppressed HCC cell proliferation, migration, and invasion
Molecular mechanism: hsa-miR-497-5p was a direct target of circ-CCND1 and hsa-miR-497-5p specifically modulated HMGA2 expression
Survival: poor
Supported No.:
 1
Description:

Circ-CCND1 plays a cancer-promoting role in HCC by modulating the miR-497-5p/HMGA2 axis.
Other information
Title:

CircRNA Circ-CCND1 Aggravates Hepatocellular Carcinoma Tumorigenesis by Regulating the miR-497-5p/HMGA2 Axis.

Journal: Mol Biotechnol
Published: 2021/9/27
PubMed ID: 34564768