circRNA basic information
circBase ID: -
Name: hsa_circ_Tshz2-2
Synonym: circTshz2-2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9970
DO name: obesity
Disease details: obesity
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BDNF
Associated microRNA: -
Biological function: Suppression of circTshz2-2 increased BDNF expression and reduced G2/M checkpoint proteins such as Cyclin B2 and CDK1 through BDNF/TrkB signaling pathway, resulting in cell cycle arrest and neurite elongation.
Molecular mechanism: circTshz2-2 bound to the YY1 transcriptional complex and suppressed Bdnf transcription.
Survival: -
Supported No.:
 1
Description:

Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits.
Other information
Title:

Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain.

Journal: Mol Psychiatry
Published: 2021/9/26
PubMed ID: 34561612