circRNA basic information
circBase ID: hsa_circ_0004104
Name: -
Synonym: circ_0004104
Host Gene: hsa-miR-100
 
 
 
Disease basic information
DO ID:
 3393
DO name: coronary artery disease
Disease details: Coronary artery disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: VECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TNFAIP8
Associated microRNA: hsa-miR-100
Biological function: Ox-LDL could inhibit the proliferation and promote the apoptosis and inflammation of VECs to induce VEC injury. However, silenced circ_0004104 could alleviate VEC injury induced by ox-LDL.
Molecular mechanism: circ_0004104 could sponge miR-100 and a miR-100 inhibitor could reverse the inhibition effect of circ_0004104 knockdown on ox-LDL-induced VEC injury. TNFAIP8 was a target of miR-100, and miR-100 alleviated ox-LDL-induced VEC injury by targeting TNFAIP8.
Survival: -
Supported No.:
 2
Description:

Our data suggested that circ_0004104 promoted ox-LDL-induced VEC injury by the miR-100/TNFAIP8 axis, indicating that circ_0004104 might be a potential biomarker for CAD treatment.
Other information
Title:

Knockdown of circ_0004104 Alleviates Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cell Injury by Regulating miR-100/TNFAIP8 Axis.

Journal: J Cardiovasc Pharmacol
Published: 2021/9/24
PubMed ID: 34554678