circRNA basic information
circBase ID: -
Name: mmu_circ_Cdyl
Synonym: circCdyl
Host Gene: mmu-let-7c
 
 
 
Disease basic information
DO ID:
 3627
DO name: aortic aneurysm
Disease details: abdominal aortic aneurysm
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Cdyl
Associated microRNA: mmu-let-7c
Biological function: circCdyl regulates AAA formation and showed that circCdyl promotes vascular inflammation and M1 polarization by inhibiting interferon regulatory factor 4 (IRF4) entry into the nucleus, significantly inducing AAA formation.
Molecular mechanism: circCdyl was shown to act as a let-7c sponge, promoting C/EBP-delta expression in macrophages to induce M1 polarization.
Survival: -
Supported No.:
 1
Description:

Our results indicate an important role for circCdyl-mediated macrophage polarization in AAA formation and provide a potent therapeutic target for AAA treatment.
Other information
Title:

Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation.

Journal: Mol Ther
Published: 2021/9/22
PubMed ID: 34547461