circRNA basic information
circBase ID: hsa_circ_0007059
Name: -
Synonym: circ_0007059
Host Gene: hsa-miR-1278
 
 
 
Disease basic information
DO ID:
 10952
DO name: nephritis
Disease details: nephritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: SHP-1/STAT3
Associated microRNA: hsa-miR-1278
Biological function: Circ_0007059 overexpression resulted in increased cell proliferation, cell viability, apoptosis, and inflammation-associated factors (CXCL10, IFIT1, ISG15, and MX1) in RMCs and HEK293 cells
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ_0007059 protects RMCs against apoptosis and inflammation during nephritis by attenuating miR-1278/SHP-1/STAT3 signaling.
Other information
Title:

Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling.

Journal: Mol Med
Published: 2021/9/19
PubMed ID: 34535085