circRNA basic information
circBase ID: -
Name: hsa_circ_NOP10
Synonym: circNOP10
Host Gene: hsa-miR-204
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT1
Associated microRNA: hsa-miR-204
Biological function: promoted proliferation and migration as well as epithelial-mesenchymal transition (EMT) through the NF-kappabeta pathway in GC cell lines
Molecular mechanism: by activating the hsa-miR-204/SIRT1 pathway
Survival: poor
Supported No.:
 1
Description:

Candidate oncogene circNOP10 mediated GC cell proliferation, arrest cell cycle in G(2)/M phase, induced cell apoptosis, enhanced tumor metastasis, as well as EMT by activating the miR-204/SIRT1 pathway, suggesting that it may serve as a potential biomarker in GC therapy.
Other information
Title:

Candidate oncogene circularNOP10 mediates gastric cancer progression by regulating miR-204/SIRT1 pathway.

Journal: J Gastrointest Oncol
Published: 2021/9/18
PubMed ID: 34532100