circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: circRNA LARP4
Host Gene: hsa-miR-367
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (A549, NCI-H1650, NCI-H1299, HCC827), human normal lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-367
Biological function: In NCI-H1650 cells, circRNA LARP4 overexpression inhibited cell proliferation, migration, and invasion, while promoting apoptosis. In A549 cells, circRNA LARP4 knockdown increased cell proliferation, migration, and invasion, while decreasing apoptosis.
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 4
Description:

circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC.
Other information
Title:

Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer.

Journal: Int J Clin Exp Pathol
Published: 2021/9/17
PubMed ID: 34527128