circRNA basic information
circBase ID: hsa_circ_0022742
Name: -
Synonym: -
Host Gene: hsa-miR-503-5p
 
 
 
Disease basic information
DO ID:
 9351
DO name: diabetes mellitus
Disease details: diabetes
Species: human
Species details: human
Sample type: cell line
Sample type details: human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FBXW7
Associated microRNA: hsa-miR-503-5p
Biological function: Both overexpression of FBXW7 and inhibition of miR-503-5p reversed the protective effect of hsa_circ_0022742 against HG-induced endothelial dysfunction, including apoptosis, abnormal vascular differentiation, and secretion of inflammatory factors
Molecular mechanism: hsa_circ_0022742 enhanced FBXW7 expression by sponging miR-503-5p
Survival: -
Supported No.:
 1
Description:

these findings demonstrate that overexpression of hsa_circ_0022742 suppressed HG-induced endothelial dysfunction by targeting the miR-503-5p/FBXW7 axis.
Other information
Title:

Overexpression of hsa_circ_0022742 suppressed hyperglycemia-induced endothelial dysfunction by targeting the miR-503-5p/FBXW7 axis.

Journal: Microvasc Res
Published: 2021/9/14
PubMed ID: 34516983