circRNA basic information
circBase ID: -
Name: hsa_circ_TUBGCP3
Synonym: CircTUBGCP3
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 1993
DO name: rectum cancer
Disease details: rectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human rectal mucosa epithelium cells FHC, rectal cancer cells (SW837, SW1463)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: hsa-miR-375
Biological function: CircTUBGCP3 interference inhibited the colony formation ability, migration, invasion, cell cycle progression, and glycolysis and promoted the apoptosis in rectal cancer cells
Molecular mechanism: CircTUBGCP3 negative regulated microRNA-375 (hsa-miR-375) expression through interacting with it and circTUBGCP3 silencing-mediated effects in rectal cancer cells were largely based on the up-regulation of hsa-miR-375.
Survival: -
Supported No.:
 1
Description:

CircTUBGCP3 acted as an oncogene to promote the malignant phenotypes of rectal cancer cells by modulating miR-375/ROCK1 axis.
Other information
Title:

CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.

Journal: Dig Dis Sci
Published: 2021/9/14
PubMed ID: 34515875