circRNA basic information
circBase ID: -
Name: hsa_circ_ARF3
Synonym: circARF3
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: subarachnoid hemorrhage
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MyD88
Associated microRNA: hsa-miR-31-5p
Biological function: overexpressing circARF3 attenuated OGD-mediated integrity destruction of BMECs and microglial induced neuroinflammation, while overexpressing miR-31-5p had opposite effects.
Molecular mechanism: circARF3 sponged miR-31-5p as an endogenous competitive RNA and dampens its expression, thus inactivating MyD88-NF-¦ĘB pathway.
Survival: -
Supported No.:
 1
Description:

CircARF3 attenuates BBB destruction in SAH rats by regulating the miR-31-5p-activated MyD88-NF-¦ĘB pathway.
Other information
Title:

Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-kappaB axis.

Journal: Aging (Albany NY)
Published: 2021/9/14
PubMed ID: 34511434