circRNA basic information
circBase ID: hsa_circ_0004712
Name: hsa_circ_PDE7B
Synonym: -
Host Gene: hsa-miR-331-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OC cell lines (OVCAR-3, SKOV-3), normal ovarian epithelial cells (IOSE-80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD4
Associated microRNA: hsa-miR-331-3p
Biological function: Downregulation of hsa_circ_0004712 impaired OC cell proliferation, colony formation, invasion and migration, and accelerated apoptosis.
Molecular mechanism: by mediating the hsa-miR-331-3p/FZD4 pathway
Survival: -
Supported No.:
 1
Description:

hsa_circ_0004712 deficiency repressed OC development by mediating the miR-331-3p/FZD4 pathway, predicting that hsa_circ_0004712 was a promising biomarker for OC diagnosis and therapy.
Other information
Title:

Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway.

Journal: J Ovarian Res
Published: 2021/9/12
PubMed ID: 34507595