circRNA basic information
circBase ID: -
Name: hsa_circ_GNG7
Synonym: circGNG7
Host Gene: -
 
 
 
Disease basic information
DO ID:
 5520
DO name: head and neck squamous cell carcinoma
Disease details: head and neck squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HNSCC cell lines (SCC4, SCC9, CAL27, CAL33)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: SMAD
Associated microRNA: -
Biological function: overexpression of circGNG7 strongly inhibited tumor cell proliferation, colony formation, in vitro migration, and in vivo tumor growth.
Molecular mechanism: the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4 (SMAD4)
Survival: better
Supported No.:
 1
Description:

A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82.
Other information
Title:

A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82.

Journal: Cancer Commun (Lond)
Published: 2021/9/10
PubMed ID: 34498800