circRNA basic information
circBase ID: -
Name: hsa_circ_PGC
Synonym: Circ-PGC
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXR2
Associated microRNA: hsa-miR-532-3p
Biological function: Circ-PGC knockdown or FOXR2 knockdown inhibited NSCLC cell viability, colony formation, cell migration, invasion and glycolysis metabolism, and FOXR2 overexpression rescued these inhibitory effects caused by circ-PGC knockdown.
Molecular mechanism: circ-PGC positively regulated FOXR2 expression by targeting hsa-miR-532-3p
Survival: -
Supported No.:
 1
Description:

circ-PGC positively regulated FOXR2 expression by competitively binding to miR-532-3p, thereby promoting the development of NSCLC, and the Wnt/beta-catenin signaling pathway might be activated by the circ-PGC/miR-532-3p/FOXR2 network.
Other information
Title:

Circ-PGC increases the expression of FOXR2 by targeting miR-532-3p to promote the development of non-small cell lung cancer.

Journal: Cell Cycle
Published: 2021/9/9
PubMed ID: 34494941