circRNA basic information
circBase ID: -
Name: mmu_circ_Fryl
Synonym: circ-Fryl
Host Gene: mmu-miR-490-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: lung injury
Species: mouse
Species details: mouse
Sample type: cell line
Sample type details: adipose-derived stem cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT3
Associated microRNA: mmu-miR-490-3p
Biological function: Downregulation of circ-Fryl suppressed ADSC protective effects exosomes against sepsis-induced lung injury by decreasing apoptosis and inflammatory factor expression.
Molecular mechanism: miR-490-3p overexpression or SIRT3 silencing reversed ADSC exosome protective effects.
Survival: -
Supported No.:
 1
Description:

our results suggest that exosomes derived from ADSCs attenuate sepsis-induced lung injury by delivery of circ-Fryl and regulation of the miR-490-3p/SIRT3 pathway.
Other information
Title:

Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway.

Journal: Inflammation
Published: 2021/9/4
PubMed ID: 34478012