circRNA basic information
circBase ID: hsa_circ_0000491
Name: -
Synonym: circ_0000491
Host Gene: hsa-miR-455-3p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: Diabetic nephropathy
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: SV40-MES13 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Hmgb1
Associated microRNA: hsa-miR-455-3p
Biological function: Knockdown of circ_0000491 weakened HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells.
Molecular mechanism: miR-455-3p was a direct target of circ_0000491, and miR-455-3p inhibition could reverse the role of circ_0000491 silencing in HG-induced SV40-MES13 cells.
Survival: -
Supported No.:
 1
Description:

Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR-455-3p/Hmgb1 axis.
Other information
Title:

Circ_0000491 Promotes Apoptosis, Inflammation, Oxidative Stress, and Fibrosis in High Glucose-Induced Mesangial Cells by Regulating miR-455-3p/Hmgb1 Axis.

Journal: Nephron
Published: 2021/9/3
PubMed ID: 34474408