circRNA basic information
circBase ID: -
Name: hsa_circ_PTPN22
Synonym: circPTPN22
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3/SIRT1
Associated microRNA: -
Biological function: Knockdown of circPTPN22 inhibited cell proliferation and attenuates pancreatic cancer immune microenvironment
Molecular mechanism: promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction
Survival: -
Supported No.:
 1
Description:

STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction.
Other information
Title:

circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation.

Journal: Cancer Gene Ther
Published: 2021/9/3
PubMed ID: 34471233