circRNA basic information
circBase ID: -
Name: hsa_circ_SEC24A
Synonym: CircSEC24A
Host Gene: hsa-miR-455-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PPM1F
Associated microRNA: hsa-miR-455-3p
Biological function: circSEC24A silencing decreased xenograft tumor growth in vivo and repressed proliferation, metastasis, invasion, epithelial-to-mesenchymal transition (EMT), induced cell cycle arrest, and apoptosis of HCC cells in vitro
Molecular mechanism: circSEC24A acted as a molecular sponge to sequester hsa-miR-455-3p, resulting in elevating the expression of PPM1F
Survival: -
Supported No.:
 4
Description:

circSEC24A sponged miR-455-3p to elevate the PPM1F expression, resulting in accelerating malignant behaviors of HCC cells.
Other information
Title:

CircSEC24A promotes tumor progression through sequestering miR-455-3p in hepatocellular carcinoma.

Journal: Neoplasma
Published: 2021/8/31
PubMed ID: 34459207