circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: circ_101057
Host Gene: hsa-miR-424-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human gastric epithelial cell line (GES-1), GC cell lines (SGC-7901, MKN-45, MKN-28, HGC-27, MGC-803, AGS, BGC-823)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: LATS1
Associated microRNA: hsa-miR-424-5p
Biological function: inhibits cell proliferation and invasion
Molecular mechanism: sponging hsa-miR-424-5p and regulating LATS1 expression
Survival: better
Supported No.:
 1
Description:

CircLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients.
Other information
Title:

Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.

Journal: Mol Cancer
Published: 2017/9/13
PubMed ID: 28893265