circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HEK-293_T, HeLa, HCT-116, Huh-7
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-124
Biological function: regulates cell growth
Molecular mechanism: circHIPK3 directly binds to hsa-miR-124 and inhibits hsa-miR-124 activity, miRNA sponge
Survival: -
Supported No.:
 6
Description:

A subsequent cell proliferation assay indicated that the downregulation of circHIPK3, but not HIPK3 mRNA, significantly suppressed cell growth in different cell types. Consistent with this result from the siRNA knockdown experiments, we observed that cell proliferation was significantly suppressed on the knockdown of circHIPK3 expression in HEK-293T cells via CRISPR/Cas9 technology.
Other information
Title:

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.

Journal: Nat Commun
Published: 2016/4/7
PubMed ID: 27050392