circRNA basic information
circBase ID: -
Name: hsa_circ_GALNT16
Synonym: Circ-GALNT16
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: Serpine1
Associated microRNA: -
Biological function: Circ-GALNT16 suppressed the proliferation and metastatic ability of CRC cells in vitro and in vivo
Molecular mechanism: circ-GALNT16 could bind to the KH3 domain of heterogeneous nuclear ribonucleoprotein K (hnRNPK), which promoted the SUMOylation of hnRNPK
Survival: better
Supported No.:
 1
Description:

Circ-GALNT16 suppressed CRC progression by inhibiting Serpine1 expression through regulating the sequence-specific DNA binding ability of the SENP2-mediated hnRNPK-p53 transcriptional complex and might function as a biomarker and therapeutic target for CRC.
Other information
Title:

Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.

Journal: J Exp Clin Cancer Res
Published: 2021/8/29
PubMed ID: 34452628