circRNA basic information
circBase ID: hsa_circ_0057558
Name: -
Synonym: Circ_0057558
Host Gene: hsa-miR-206
 
 
 
Disease basic information
DO ID:
 80208
DO name: non-alcoholic fatty liver disease
Disease details: nonalcoholic fatty liver disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1/AMPK signaling
Associated microRNA: hsa-miR-206
Biological function: Knockdown of circ_0057558 or overexpression of miR-206 inhibited lipogenesis, TG secretion and expression of lipogenesis-related proteins
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0057558 acts as a miR-206 sponge to de-repress the ROCK1/AMPK signaling and facilitates lipogenesis and TG secretion, which greatly contributes to NAFLD development and progression.
Other information
Title:

Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206.

Journal: Cell Death Dis
Published: 2021/8/28
PubMed ID: 34446693