circRNA basic information
circBase ID: hsa_circ_0003222
Name: hsa_circ_LARP4
Synonym: -
Host Gene: hsa-miR-527
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung cancer cells (PC9, A549 cells)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PHF21B
Associated microRNA: hsa-miR-527
Biological function: Reduced levels of hsa_circ_0003222 decreased tumor cell proliferation, migration, invasion, stemness-like properties, and chemoresistance
Molecular mechanism: The silencing of hsa_circ_0003222 was found to downregulate PHF21B expression and its downstream, beta-catenin by relieving the sponging effect of hsa-miR-527
Survival: -
Supported No.:
 4
Description:

hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527.
Other information
Title:

hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527.

Journal: Cell Death Dis
Published: 2021/8/27
PubMed ID: 34433810