circRNA basic information
circBase ID: hsa_circ_0003972
Name: hsa_circ_FAM120A
Synonym: circ-FAM120A
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 848
DO name: arthritis
Disease details: arthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: RA fibroblast-like synoviocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MDM4
Associated microRNA: hsa-miR-671-5p
Biological function: Circ-FAM120A upregulation, miR-671-5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression.
Molecular mechanism: paeoniflorin attenuated RA-FLS progression by regulating the circ-FAM120A/miR-671-5p/MDM4 axis
Survival: -
Supported No.:
 2
Description:

Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway.
Other information
Title:

Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis.

Journal: Inflammation
Published: 2021/8/24
PubMed ID: 34423389