circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: hsa-miR-320b
 
 
 
Disease basic information
DO ID:
 11612
DO name: polycystic ovary syndrome
Disease details: Polycystic ovary syndrome
Species: human
Species details: human
Sample type: cell line
Sample type details: human granulosa-like tumor cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MCL1
Associated microRNA: hsa-miR-320b
Biological function: circMTO1 knockdown promoted human granulosa-like tumor cell proliferation and inhibited its apoptosis rate
Molecular mechanism: expression of circMTO1 was induced by Snail family transcriptional repressor 2 (SNAI2) in human granulosa-like tumor cells.
Survival: -
Supported No.:
 1
Description:

Our results may provide potential targets for PCOS research and a novel direction for the diagnosis and treatment of PCOS.
Other information
Title:

SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells.

Journal: Front Genet
Published: 2021/8/21
PubMed ID: 34413875