circRNA basic information
circBase ID: hsa_circ_0099999
Name: -
Synonym: circ_0099999
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FSCN1
Associated microRNA: hsa-miR-330-5p
Biological function: Knockdown of circ_0099999 impeded cell proliferation, migration, invasion, glycolysis, and promoted apoptosis in vitro, as well as diminished tumour growth in vivo
Molecular mechanism: circ_0099999 operated as a ceRNA for hsa-miR-330-5p to modulate FSCN1 expression
Survival: -
Supported No.:
 2
Description:

Our findings established a novel causal mechanism, circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk, in regulating pancreatic carcinogenesis and provided that inhibition of circ_0099999 might have therapeutic benefits in pancreatic cancer.
Other information
Title:

A novel circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk in pancreatic cancer.

Journal: Autoimmunity
Published: 2021/8/20
PubMed ID: 34409897