circRNA basic information
circBase ID: -
Name: hsa_circ_DONSON
Synonym: Circ-DONSON
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LDHA
Associated microRNA: hsa-miR-149-5p
Biological function: silenced circ-DONSON could inhibit the proliferation, metastasis and angiogenesis, while enhance the apoptosis and radiosensitivity of GC cells
Molecular mechanism: circ-DONSON could sponge hsa-miR-149-5p, which could target LDHA in GC
Survival: -
Supported No.:
 3
Description:

circ-DONSON could facilitate GC progression by increasing LDHA expression via sponging miR-149-5p, indicating that circ-DONSON might be a novel biomarker for GC treatment.
Other information
Title:

Circ-DONSON Facilitates the Malignant Progression of Gastric Cancer Depending on the Regulation of miR-149-5p/LDHA Axis.

Journal: Biochem Genet
Published: 2021/8/20
PubMed ID: 34409524