circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR1
Synonym: circLPAR1
Host Gene: hsa-miR-212-3p
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CHP-212 and IMR-32 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZNF217
Associated microRNA: hsa-miR-212-3p
Biological function: Knockdown of circLPAR1 suppressed Abeta25-35-induced neuronal apoptosis, inflammation, and oxidative stress.
Molecular mechanism: circLPAR1 competitively bound to miR-212-3p to elevate its target ZNF217. Rescue experiments suggested that miR-212-3p inhibition reversed circLPAR1 silencing-evoked inhibition on neuronal injury under Abeta25-35 stimulation
Survival: -
Supported No.:
 2
Description:

CircLPAR1 promotes Abeta25-35-induced apoptosis, inflammation, and oxidative stress via miR-212-3p/ZNF217 axis, suggesting a new insight into the pathogenesis of AD.
Other information
Title:

CircLPAR1/miR-212-3p/ZNF217 feedback loop promotes amyloid beta-induced neuronal injury in Alzheimer Disease.

Journal: Brain Res
Published: 2021/8/18
PubMed ID: 34403662