circRNA basic information
circBase ID: -
Name: hsa_circ_SFMBT2
Synonym: circ-SFMBT2
Host Gene: hsa-miR-885-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CHD7
Associated microRNA: hsa-miR-885-3p
Biological function: circ-SFMBT2 knockdown suppressed gastric cancer cell viability, colony formation ability, migration, invasion and oxidative stress but induced apoptosis, and circ-SFMBT2 downregulation also blocked tumor growth in vivo
Molecular mechanism: circ-SFMBT2 regulated CHD7 expression by sponging its target miRNA, hsa-miR-885-3p
Survival: -
Supported No.:
 4
Description:

Circ-SFMBT2 downregulation repressed the development of gastric cancer partially by controlling the miR-885-3p/CHD7 axis, which might be a novel strategy to inhibit gastric cancer progression.
Other information
Title:

Downregulation of circ-SFMBT2 blocks the development of gastric cancer by targeting the miR-885-3p/CHD7 pathway.

Journal: Anticancer Drugs
Published: 2021/8/14
PubMed ID: 34387601