circRNA basic information
circBase ID: -
Name: hsa_circ_FAM120B
Synonym: CircFAM120B
Host Gene: hsa-miR-645
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TGFBR2
Associated microRNA: hsa-miR-645
Biological function: CircFAM120B overexpression blocked CRC cell proliferation, migration/invasion, and glycolysis metabolism
Molecular mechanism: by targeting the hsa-miR-645/TGFBR2 axis
Survival: -
Supported No.:
 2
Description:

circFAM120B activated the expression of TGFBR2 by targeting miR-645. TGFBR2 also blocked tumor growth in vivo by targeting the miR-645/TGFBR2 axis.
Other information
Title:

CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645.

Journal: Front Cell Dev Biol
Published: 2021/8/13
PubMed ID: 34381772