circRNA basic information
circBase ID: -
Name: hsa_circ_THBS1
Synonym: CircTHBS1
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 13949
DO name: interstitial cystitis
Disease details: interstitial cystitis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MFN2
Associated microRNA: hsa-miR-139-5p
Biological function: CircTHBS1 could promote the proliferation, migration, EMT process, and inflammation of IC cells, while its knockdown had an opposite effect
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circTHBS1 sponged miR-139-5p to positively regulate MFN2. CircTHBS1 promoted IC cell proliferation, migration, EMT process, and inflammation by regulating the miR-139-5p/MFN2 axis indicating that circTHBS1 might be a potential target for IC treatment.
Other information
Title:

CircTHBS1 facilitates the progression of interstitial cystitis depending on the regulation of miR-139-5p/MFN2 axis.

Journal: Drug Dev Res
Published: 2021/8/10
PubMed ID: 34368980