circRNA basic information
circBase ID: -
Name: hsa_circ_CDK14
Synonym: -
Host Gene: hsa-miR-520a-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GAB1
Associated microRNA: hsa-miR-520a-3p
Biological function: Circ_CDK14 depletion hindered OS cell proliferation, metastasis, and tumorigenesis while facilitated apoptosis
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 5
Description:

Circ_CDK14 could sponge miR-520a-3p. miR-520a-3p targeted GAB1 to repress OS cell proliferation and metastasis. Circ_CDK14 knockdown blocked OS tumor growth in vivo. Circ_CDK14 might positively affect OS development by modulating the miR-520a-3p/GAB1 axis.
Other information
Title:

Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.

Journal: Neoplasma
Published: 2021/8/6
PubMed ID: 34348465