circRNA basic information
circBase ID: hsa_circ_0025908
Name: -
Synonym: Circ_0025908
Host Gene: hsa-miR-137
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HIPK2
Associated microRNA: hsa-miR-137
Biological function: circ_0025908 deficiency inhibited cell vitality, cell mitotic cycle, cell proliferation, and immunoreaction in RA cells, whereas promoted cell apoptosis
Molecular mechanism: circ_0025908 acted as a hsa-miR-137 sponge to regulate the level of HIPK2
Survival: -
Supported No.:
 2
Description:

Circ_0025908 facilitates the development of RA through increasing HIPK2 expression by regulating miR-137, which also offered an underlying targeted therapy for RA treatment.
Other information
Title:

Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis.

Journal: J Orthop Surg Res
Published: 2021/8/1
PubMed ID: 34330307