circRNA basic information
circBase ID: -
Name: hsa_circ_N4BP2L2
Synonym: CircN4BP2L2
Host Gene: hsa-miR-340-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HT-29 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCR4
Associated microRNA: hsa-miR-340-5p
Biological function: inhibition of circN4BP2L2 effectively inhibited proliferation, migration, and invasion of LoVo cells, and inhibited tumor growth and metastasis in vivo, whereas the forced expression of circN4BP2L2 facilitated the proliferation, migration, and invasion of HT-29 cells
Molecular mechanism: circN4BP2L2 acted as a molecular sponge of hsa-miR-340-5p to competitively promote CXCR4 expression
Survival: -
Supported No.:
 1
Description:

Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR-340-5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment.
Other information
Title:

CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis.

Journal: Lab Invest
Published: 2021/7/31
PubMed ID: 34326457