circRNA basic information
circBase ID: -
Name: hsa_circ_IKBKB
Synonym: circIKBKB
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer bone metastasis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Overexpressing circIKBKB enhanced the capability of BC cells to induce formation of bone pre-metastatic niche dramatically by promoting osteoclastogenesis in vivo and in vitro
Molecular mechanism: circIKBKB activated NF-kappaB pathway via promoting IKKbeta-mediated IkappaBalpha phosphorylation, inhibiting IkappaBalpha feedback loop and facilitating NF-kappaB to the promoters of multiple bone remodeling factors
Survival: -
Supported No.:
 1
Description:

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappaB/bone remodeling factors signaling.
Other information
Title:

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappaB/bone remodeling factors signaling.

Journal: Mol Cancer
Published: 2021/7/31
PubMed ID: 34325714