circRNA basic information
circBase ID: hsa_circ_0003972
Name: -
Synonym: circ_0003972
Host Gene: hsa-miR-654-5p
 
 
 
Disease basic information
DO ID:
 848
DO name: arthritis
Disease details: arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HFLS-RA cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD4
Associated microRNA: hsa-miR-654-5p
Biological function: Circ_0003972 knockdown inhibited the proliferation, inflammation, while promoted the apoptosis of TNF¦Á-induced HFLS-RA cells.
Molecular mechanism: MiR-654-5p was downregulated in RA patients and HFLS-RA cells, and it could be sponged by circ_0003972.Frizzled-4 (FZD4) could be targeted by miR-654-5p, and its expression was positively regulated by circ_0003972.
Survival: -
Supported No.:
 2
Description:

Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.
Other information
Title:

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis.

Journal: Immunol Invest
Published: 2021/7/31
PubMed ID: 34325604