circRNA basic information
circBase ID: hsa_circ_0007031
Name: -
Synonym: Circ_0007031
Host Gene: hsa-miR-485-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MELK
Associated microRNA: hsa-miR-485-3p
Biological function: circ_0007031 overexpression promoted cell proliferation and induced cell arrest at S phase
Molecular mechanism: Circ_0007031 controlled MELK expression via interacting with hsa-miR-485-3p
Survival: -
Supported No.:
 4
Description:

Circ_0007031 knockdown repressed CRC malignant progression by reducing MELK expression through associating with miR-485-3p, suggesting that circ_0007031 was a potential target for the therapy of CRC.
Other information
Title:

Circ_0007031 Silencing Inhibits Cell Proliferation and Induces Cell Apoptosis via Downregulating MELK at a miR-485-3p-Dependent Way in Colorectal Cancer.

Journal: Biochem Genet
Published: 2021/7/30
PubMed ID: 34322757