circRNA basic information
circBase ID: hsa_circ_0136666
Name: -
Synonym: -
Host Gene: hsa-miR-497
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-L1
Associated microRNA: hsa-miR-497
Biological function: -
Molecular mechanism: Hsa_circ_0136666 was demonstrated to directly target hsa-miR-497, which also regulated PD-L1 by binding to its 3UTR.
Survival: -
Supported No.:
 3
Description:

hsa_circ_0136666 promoted the expression of PD-L1 by inhibiting miR-497 level in colorectal cancer, thus inducing the activation of Treg cells and leading to the immune escape of tumor, providing a novel mechanistic insight into the pathogenesis of colorectal cancer.
Other information
Title:

Hsa_circ_0136666 activates Treg-mediated immune escape of colorectal cancer via miR-497/PD-L1 pathway.

Journal: Cell Signal
Published: 2021/7/29
PubMed ID: 34320370