circRNA basic information
circBase ID: -
Name: hsa_circ_MMP11
Synonym: Circ-MMP11
Host Gene: hsa-miR-153-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ANLN
Associated microRNA: hsa-miR-153-3p
Biological function: circ-MMP11 knockdown promoted lapatinib sensitivity by repressing cell viability, colony number, migration, invasion, and boosting apoptosis in LR breast cancer cells.
Molecular mechanism: circ-MMP11 could regulate ANLN expression through sponging hsa-miR-153-3p
Survival: -
Supported No.:
 4
Description:

Circ-MMP11 could be transferred by exosomes in breast cancer cells. And circ-MMP11 functioned as a sponge of miR-153-3p to regulate ANLN expression, thereby promoting lapatinib resistance in breast cancer cells, providing therapeutic targets for the treatment of breast cancer.
Other information
Title:

Circular RNA circ-MMP11 Contributes to Lapatinib Resistance of Breast Cancer Cells by Regulating the miR-153-3p/ANLN Axis.

Journal: Front Oncol
Published: 2021/7/24
PubMed ID: 34295807